The NFL Week 4 odds present intriguing spots for astute bettors to target, from road favorites aiming to stay perfect to desperate underdogs fighting for survival. The undefeated Kansas City Chiefs and Las Vegas Raiders highlight the slate in a massive AFC West clash. Meanwhile, winless squads like the Tennessee Titans, Miami Dolphins, Los Angeles Chargers, Houston Texans, and Tampa Bay Buccaneers enter early must-win territory.

Action kicks off on October 2 when the Pittsburgh Steelers visit the Cleveland Browns. Handicapping the card runs through the week’s finale, an NFC South rivalry between the Atlanta Falcons and New Orleans Saints on October 6.

Below, I have set out my straight-up pick for all 16 games on the Week 4 slate (our last week without byes until Week 14).

My Week 4 NFL picks are a blend of nine favorites and seven underdogs, with the 3-0 Raiders representing my biggest longshot of the week, priced at just 34¢ (equal to +194 odds) to win at home against the fellow 3-0 Chiefs.

The table below summarizes my SU picks record for the season as a whole, broken down by week.

The next sections dive deeper into my top-three favorites to back in Week 4, followed by my three best upset predictions.

The San Francisco 49ers (3-0 SU, 2-1 ATS) have operated as the league’s most-dominant team through the opening three weeks, pacing the NFL with a blistering +16.0 scoring margin per game and an explosive 7.35 offensive yards per play.

That high-octane production translates to a league-leading net efficiency margin of +2.51 yards per play over an opponent unit allowing under five yards per snap. Conversely, the Denver Broncos (2-1 SU, 2-1 ATS) arrive with a misleading winning record that masks severe offensive stagnation, producing just 4.97 yards per play while being outscored on the season (-3.3 point differential per game).