The NFL Week 6 odds are starting to trickle out. The table below lists the opening spread, moneyline, and game total for all games on the Week 6 schedule.

Four teams are on bye – Cincinnati Bengals, Detroit Lions, Miami Dolphins, and Minnesota Vikings – leaving 14 games on the slate, starting with the Seattle Seahawks vs Denver Broncos on TNF and wrapping up with the Washington Commanders vs San Francisco 49ers on Monday. The Jacksonville Jaguars will play their second straight game in London when they “host” the Houston Texans, while the Green Bay Packers and Dallas Cowboys meet on SNF.

Odds as of Oct 11 at DraftKings. Claim the best NFL betting promos ahead of Week 6.

Opening odds for all 14 Week 6 games are now on the board.

Week 6 action kicks off at Empower Field at Mile High on Thursday night, where the Seattle Seahawks (3-2, 1-2-2 ATS, 2-3 O/U) open as slim 1.5-point road favorites (-110) over the Denver Broncos (2-2, 2-2 ATS, 1-3 O/U) in the opening TNF odds . (Note that both teams are trailing in the second-halves of their Week 5 games.)

DraftKings has installed Seattle at -122 on the moneyline (55.0% implied win probability), with Denver returning as a slight home underdog at +102 (49.5% implied win probability).

The game total has opened at a modest 41.5 points with standard -110 juice on both sides, representing one of the lowest totals across the Week 6 board. The under has been the dominant trend for Denver, hitting in three of their first four games (10-31 at KC, 20-13 vs JAX, and 14-24 at SF) and looking good to cash again against LAC in Week 5. (The Chargers lead 17-10 heading into the fourth, meaning the teams will need to combine for 16 fourth-quarter points go over the 42.5-point total). The Bronco defense continues to keep games within reach despite an offense averaging under 19 PPG.

Seattle enters at 2-3 O/U, showing pronounced matchup splits – pushing past 50+ total points in high-flying shootouts against Washington (64) and the Chargers (53), while staying comfortably under against New England (23), Arizona (38), and San Francisco (34). Against Denver’s disciplined secondary in the thin Rocky Mountain air, oddsmakers project a lower-scoring, possession-by-possession Thursday night clash.