Michigan State visits Notre Dame Stadium on Saturday, September 19, for a 7:30 p.m. ET kickoff on NBC. Both teams are unbeaten, but the betting line suggests a substantial gap between them.

Notre Dame has outscored its first two opponents 93-13 behind an efficient start from quarterback CJ Carr. Michigan State counters with Cam Edwards’ production on the ground and an offense that has found ways to keep possessions alive.

My Michigan State vs Notre Dame prediction separates the likely winner from the better spread bet. The latest BetMGM odds are below, followed by my picks for the margin and total.

Odds from BetMGM , subject to change. Check the current BetMGM offers .

Notre Dame needs a 30-point victory to cover -29, while a margin of exactly 29 would push either spread bet. Michigan State can lose by four touchdowns and still cover. That is a meaningful cushion even against an opponent that has opened with consecutive comfortable wins.

The total is 52.5, with the Under priced at -118. I am keeping the spread and total as separate bets. They share a similar expectation of how Michigan State can compete, but either can win without the other cashing.

I’m taking Michigan State +29 and Under 52.5. Edwards has rushed for 250 yards through the Spartans’ first two games. The Spartans need that running game to produce useful early-down gains rather than leave the offense facing repeated third-and-long situations. Staying on schedule would give them a better chance to keep Notre Dame’s offense off the field.

Alessio Milivojevic has completed 70.4% of his passes, giving Michigan State another way to extend possessions. The Spartans have converted 16 third downs and five fourth downs through two games. Those are conversion totals, rather than rates, but they show the offense has kept drives alive beyond its first series of downs.