Week 4 of the 2026 NFL season is already underway following a competitive Thursday night clash where the Cleveland Browns improved to 3-1 and claimed the top spot in the AFC North by holding off the Pittsburgh Steelers 27-24. I bet Browns +3, and I am looking to keep that momentum going into Sunday’s action.

The remaining slate kicks off early on Sunday, October 4, at 9:30 AM ET when the Indianapolis Colts meet the Washington Commanders in London, and concludes on Monday at 8:15 PM ET with the Atlanta Falcons visiting the New Orleans Saints. We have a lot of football left this weekend.

Week 4 is headlined by a massive AFC West showdown between the Kansas City Chiefs and the Las Vegas Raiders. Both teams enter Sunday undefeated on three-game winning streaks, battling for early conference and division supremacy. Elsewhere, the 0-3 Texans are looking for their first win in an in-state clash with the Cowboys.

Keep reading for spreads and an against-the-spread pick for every remaining game on the schedule, plus my three favorite ATS picks broken down in detail for Sunday’s massive slate.

These spreads are current as of publication and are subject to movement. Use our DraftKings promo to back your favorite spots this weekend.

Three ATS picks stick out to me this week: Houston as a short home favorite, plus the Giants and Raiders as home underdogs.

Houston is 0-3 but is a three-point home favorite. Dallas has posted the stronger offense through three games, as the Cowboys average 28.7 points and 330.3 yards per game, but the stout Texans defense will be motivated to get their first win of the year.

The Texans’ ability to disrupt Dallas needs to be mentioned. Houston has recorded 11 sacks to Dallas’ two, and holds a +2 turnover differential versus Dallas at even. The Texans have recovered three fumbles and intercepted one pass. A pass rush that can generate negative plays and create extra possessions offers Houston a way to take over this game. Houston has also accumulated 65 first downs to Dallas’ 68 and gained 978 total yards to Dallas’ 991, so the yardage gap is narrow despite the scoring difference.