South Florida visits UTSA tonight, with kickoff at 7:30 p.m. ET at the Alamodome. The conference matchup brings an active road pass rush against a productive home offense.

UTSA comes off a win over Rice, while South Florida looks to rebound from a loss to Temple. The total has moved sharply since opening, and that’s one of the markets I’m focusing on for this matchup.

Below are my South Florida vs UTSA prediction, odds and Thursday CFB picks for Oct. 8.

My South Florida vs UTSA prediction backs the Roadrunners to control the game inside the Alamodome. UTSA averages an impressive 384.6 total offensive yards and 31.4 points per game. Their ground attack thrives in the red zone, helping sustain their 87.5% scoring efficiency inside the 20-yard line.

When South Florida has the ball, they face a severe matchup disadvantage. South Florida will have to navigate a ball-hawking UTSA secondary that has already snatched five interceptions this season. Quarterback Michael Van Buren is staring down a modest college football player prop of just 182.5 passing yards. This indicates oddsmakers expect a long night for the visiting offense against this aggressive defensive scheme.

While South Florida brings a formidable pass rush with nine sacks on the year, they lack the overall firepower to keep pace in a fast-track dome. I expect UTSA to establish early field position, lean on their superior offensive metrics, and win comfortably.

Odds as of October 8, 2026. New users can claim the BetMGM promo code and get a bonus for tonight’s game.

The South Florida vs UTSA college football odds paint a clear picture of the expected game flow. The betting market installs UTSA as a solid seven-point favorite at an appealing -106 price tag. Backing UTSA on the spread offers significantly better value than swallowing the steep -275 moneyline juice. The retail public is surprisingly heavy on South Florida to cover, commanding over 74% of the spread money, yet the line has held firm.