The 2026 NFL season moves quickly into its fifth week of action, and DraftKings has already posted opening lines across the slate. Week 5 brings several heavyweight non-conference battles, classic division rivalries, and pivotal early-season measuring sticks.

The action begins with an NFC Thursday night clash in Arlington between the Dallas Cowboys (2-2) and Tampa Bay Buccaneers (0-4) and extends through an action-packed Sunday before wrapping up with Monday Night Football in Inglewood when the Buffalo Bills (3-1) visit the Los Angeles Rams (2-2).

Below is the Week 5 odds board, including available opening lines and pending matchups. The Kansas City Chiefs and Carolina Panthers are on bye. Fans won’t get another 16-game week until Week 15.

Odds as of Oct 4 at DraftKings. Claim the best NFL betting promos ahead of Week 5.

Week 5 action kicks off at AT&T Stadium on Thursday night, where the Dallas Cowboys (2-2, 3-1 ATS, 4-0 O/U) are 10-point home favorites over the Tampa Bay Buccaneers (0-4, 0-4 ATS, 2-2 O/U) in the opening TNF odds. The Week 5 NFL odds install Dallas as a massive -625 favorite on the moneyline (86.2% implied win probability), with Tampa Bay returning at +455.

The Buccaneers enter desperate to secure their first victory of the 2026 campaign after a 17-7 home loss to Green Bay in Week 4 and face an uphill battle on a short week while remaining without starting quarterback Baker Mayfield for the second consecutive game. Meanwhile, the Cowboys look to get back above .500 after coming up just short in a 23-20 road defeat against Houston.

Sunday’s international action heads across the pond to Tottenham Hotspur Stadium in London, where the Jacksonville Jaguars (3-1, 3-1 ATS, 1-3 O/U) open as 3.5-point favorites over the Philadelphia Eagles (2-2, 0-4 ATS, 3-1 O/U). Jacksonville is -180 on the moneyline (64.3% implied win probability), while Philadelphia comes back as a +150 underdog, with the game total set at 42.5.

The Jaguars enter riding high after grinding out a 16-10 road victory against Cincinnati in Week 4, whereas the Eagles aim to rebound following a 24-20 setback against the Los Angeles Rams, which saw superstar running back Saquon Barkley leave in the first quarter due to injury.