As the NFL heads into Week 3 of the 2026 regular season, sportsbooks have released initial betting lines for the upcoming slate. Opening numbers from DraftKings are now out for 15 of 16 games.

Below is the complete board of opening Week 3 NFL odds .

Odds marked with * are from FanDuel. All other NFL point spreads are from DraftKings.

The Philadelphia Eagles head to Soldier Field for a Monday Night Football clash as  4.5-point road favorites (-115 juice)  against the Chicago Bears (+4.5 at -105) in the opening MNF odds . Philadelphia’s  -218 moneyline  gives them a  68.6% implied win probability , while Chicago enters as a  +180 home underdog .

The spread sitting beyond the critical field-goal threshold heavily factors in Chicago’s quarterback situation after Caleb Williams was carted off the field during their Week 2 loss to Minnesota, leaving Tyson Bagent in line to start under center. With Bagent steering the offense against a fierce Philadelphia front, the game total opens at a suppressed  43.5 (O -110/U -110) , pointing toward a run-heavy, defensive battle under the lights.

Week 3 action kicks off at Lambeau Field on Thursday night, where the Green Bay Packers are  7-point home favorites  over the Atlanta Falcons in the opening TNF odds . DraftKings has installed Green Bay at  -325 on the moneyline (76.5% implied win probability) , with Atlanta returning at  +260 .

The spread sitting squarely on the critical key number of  7  reflects solid bookmaker confidence in Green Bay’s home-field advantage. The total is listed at  44.5 points  with standard -110 juice on both sides, suggesting a moderate scoring pace under the primetime lights in Green Bay.

The Detroit Lions open as substantial home favorites at Ford Field, laying a full touchdown ( -7 at -120 juice ) against the visiting New York Jets (+7 at even money, +100). Detroit’s  -345 moneyline  represents the heaviest favorite price among all currently posted Week 3 games on DraftKings, carrying an  implied win probability of 77.5% .