Ohio State visits unbeaten Indiana on Saturday, October 17, at noon ET on FOX. Memorial Stadium hosts two highly ranked Big Ten teams, with the 5-1 Buckeyes looking to hand the 6-0 Hoosiers their first loss.

The Ohio State vs Indiana odds on Kalshi point to a close game, with the Buckeyes a slight road favorite. A short number like that for a program with Ohio State’s pedigree makes the spread and total worth a close look.

Plenty is riding on the result in the Big Ten race and the wider college football futures market. Here is how we see the matchup, plus our top picks for Saturday.

Jump to: Ohio State vs Indiana Prediction | Ohio State vs Indiana Best Bets | Ohio State vs Indiana Odds | Betting Splits

Indiana +3.5 is our Ohio State vs Indiana prediction. On Kalshi, this is the NO side of the Ohio State -3.5 contract, so it pays as long as the Buckeyes don’t win by four or more. At 56¢, that works out to roughly -127 before fees.

Indiana’s 6-0 start and 22-game win streak are built on ball security. The Hoosiers have tied or won the turnover battle in 30 straight games, and Josh Hoover has thrown 159 straight passes without an interception. That limits the short fields that turn close games into blowouts.

Ohio State’s pass rush has also cooled, with its pressure rate falling from 37.4% in 2025 to 25.9% this season. Add an Indiana run defense allowing 78.3 yards per game since 2024, compared to 89.7 for Ohio State, and the Hoosiers have a real path to cover even if the Buckeyes win.

Our second Ohio State vs Indiana best bet is the Over. At 50¢, the price is about even money before fees. Ohio State has allowed just 11.4 points per game since 2023, but Indiana is a tougher test than most of the offenses behind that number.