It’s one of the best matchups in Week 3, as the Louisville Cardinals host the SMU Mustangs in a battle of Top 25 teams.

Both teams scored at least 56 points in their last outing. SMU beat UC Davis 56-10, and Louisville answered its opening loss to Ole Miss with a 59-13 win over Villanova.

The books currently have the 1-1 Cardinals as slight 1.5-point favorites in the College Football odds against the undefeated Mustangs.

My SMU vs Louisville prediction starts with whether the Cardinals can keep Kevin Jennings off the field.

Kickoff is set this afternoon at 3:30pm ET at L&N Federal Credit Union Stadium in Louisville, KY, in a game that will be broadcast nationally on ESPN2.

I’m backing Louisville to win by more than 1.5 points at 51¢ on Kalshi. The Cardinals showed the balance I want from a short home favorite, gaining 375 passing yards and 260 rushing yards against Villanova.

That balance matters against Jennings. Louisville can attack through the air without asking its quarterback to carry every possession, and productive early-down runs would help limit the number of chances SMU gets with the ball.

Jennings has completed 40 of 52 passes for 767 yards, eight touchdowns and two interceptions through two games. He threw for 430 yards in the 27-24 win over Florida State, so Louisville cannot expect to shut him down simply because the competition improves.