Sunday afternoon, two NFC West rivals do battle, between the 1-1 Arizona Cardinals and 2-0 San Francisco 49ers at Levi’s Stadium. Kickoff is slated for 1:05 PM PT / 4:05 PM ET on FOX and San Fran is the favorite in the NFL odds .

The 49ers roll out Brock Purdy and Christian McCaffrey, while the Cardinals answer with Jacoby Brissett and Trey McBride. Here are my favorite NFL player props picks for Sunday’s affair.

Christian McCaffrey Over 100.5 Rushing + Receiving Yards (-104, Kalshi)

The 49ers’ lead back turns this divisional matchup into his personal highlight reel, and that dominance extends far beyond this season. McCaffrey has eclipsed 100.5 scrimmage yards in eight of his last nine career meetings against the Cardinals, averaging 140.9 scrimmage yards per game in that span. In his four full games against Arizona since joining San Francisco, he has racked up 177, 187, 140, and 121 total yards, clearing this line by at least 20 yards every single time.

His dual-threat role provides an unmatched volume floor, as evidenced by his ten-catch, 15-target outing in their last head-to-head meeting. Facing a vulnerable Arizona front that surrendered 126.9 rushing yards and nearly 370 total yards per game across the entire 2025 campaign, McCaffrey is in prime position to cruise past this total once again.

If you want to back this volume floor, claim your Kalshi promo code .

Trey McBride Over 7.5 Receptions (+144, Kalshi)

Trey McBride continues to command elite receiver volume when operating outside of Glendale. Over his last eight road contests dating back through last season, McBride has drawn double-digit targets five times, averaging 8.5 receptions on 10.9 targets per game away from home. He has recorded at least eight receptions in five of his last eight starts overall, showing a consistent target ceiling that few tight ends in football can match.