Ohio State at Iowa and Miami at Clemson lead the opening Week 5 college football odds. The Buckeyes are laying two touchdowns at Kinnick Stadium, while the Hurricanes are 18.5-point road favorites in Death Valley.

There is a full SEC undercard behind them. Alabama visits Mississippi State, Florida heads to Missouri after scoring 52 points against Ole Miss, and Auburn travels to Tennessee.

The table below brings together the early Week 5 spreads, totals and moneylines. Compare these early prices with live college football odds as the rest of the slate gets priced this week.

Early Week 5 odds from DraftKings as of Sept. 27; away team listed first. Compare prices across College Football betting apps before taking a side.

These are current early quotes, not historical openers, and more games should fill in over the next few hours. Vanderbilt at Georgia carries the biggest number on the board at 24.5, with Notre Dame laying 21.5 at North Carolina right behind it.

The totals split the board neatly. Ohio State at Iowa and Michigan State at Wisconsin share the lowest total at 44.5, while Alabama at Mississippi State and Louisville at NC State share the top mark at 59.5.

For the tighter games, it is worth running a price comparison on prediction market apps . Check the contracts at Kalshi and Polymarket before deciding where to take a side, matching the same outcome and accounting for fees.

The Ohio State vs Iowa odds have the Buckeyes laying two touchdowns. A 14-point win would be a push, while the 44.5 total shares the lowest mark on the board.