Week 6 of the NFL season is already rolling after a thrilling Thursday night opener, where the Denver Broncos defeated the Seattle Seahawks 17-14 in overtime after Seattle forced the extra session with a late rally. Now, bettors turn their attention to the rest of the slate, headlined by pivotal division clashes and dominant unbeatens.

The 4-0 Kansas City Chiefs, currently sitting atop the AFC, look to extend their four-game winning streak against the winless Los Angeles Chargers. Over in the NFC, the 5-0 San Francisco 49ers sit in second place and will look to push their flawless start to six straight victories.

The upcoming action kicks off across the pond on Sunday at 9:30 a.m. ET when the Houston Texans visit the Jacksonville Jaguars in London. The week concludes when those undefeated 49ers host the Washington Commanders on Monday at 8:15 p.m. ET. Below, you will find my complete list of current spreads and an against-the-spread pick for every remaining game on the board, along with a detailed breakdown of my three best ATS predictions, which include two home underdogs.

Spreads are current as of publication via BetMGM and remain subject to movement.

I believe finding great value on the spread means identifying where public perception diverges from the actual matchup data. This week, I trust a road favorite, a gritty home underdog, and a resilient home squad to cover their numbers.

The Carolina Panthers head into Philadelphia laying a short number on the road, a situational spot where I believe they offer tremendous value. The Eagles are depleted, without Jalen Hurts, Saquon Barkley, and DeVonta Smith, and face an unusual travel situation after losing in London just a week ago. That leaves Philadelphia short-handed and potentially dealing with the effects of another demanding week on the road.

Those absences strengthen the case for Carolina to control the trenches and dictate the pace. Laying 3.5 points is always a critical number in NFL odds , but I trust the Panthers’ defensive front to generate pressure and force Philadelphia into uncomfortable third-and-long situations. If the Eagles fall behind the chains, they could struggle to sustain drives against Carolina’s aggressive scheme.

I believe laying the -3.5 is the sharp side. Carolina’s offensive scheme is built to exploit defenses and finish drives with touchdowns rather than settling for field goals. Trust the Panthers to march into Philadelphia and secure a victory by at least four.