Inter Miami hosts San Diego at Nu Stadium in Miami, FL, on Sunday evening, with kickoff scheduled for 7:00 PM ET on September 20, 2026. Miami enters the matchup as a heavy favorite at home, while San Diego is a sizable underdog on the road.

Miami enters the clash second in the Eastern Conference with 45 points from a 12-9-4 record (W-D-L). Despite featuring global stars such as Lionel Messi and Luis Suarez, the hosts have struggled for consistency recently, going D-D-D-W-L-D in their last six matches. Miami leads MLS with 61 goals scored, but the team has also conceded 46, highlighting some defensive concerns.

San Diego sits ninth in the Western Conference with 30 points from an 8-6-11 record and is looking to rebound after going L-L-L-W-W-L over its last six matches. With 15 points separating the teams in the standings, Miami has a clear statistical advantage heading into this matchup.

Odds as of September 17, 2026, at 2:22 PM ET from BetMGM and Caesars .

Miami enters as the heavy favorite on the three-way moneyline, while San Diego and the draw are both priced at +400. Removing the sportsbook’s margin gives Miami a normalized 62.5% probability of winning, compared with 18.75% for both San Diego and the draw.

A $10 bet on Miami would return $15 in total, including $5 in profit. A $10 bet on San Diego would return $50, including $40 in profit.

Miami opened at -1.5 (+100) on the Asian handicap before the price moved to +105. The Over 4.5 goals market opened at -169, while the Under is now priced at -154.

For future betting markets, check out our dedicated page for  MLS Cup futures odds .