The New York Giants travel to SoFi Stadium to face the Los Angeles Rams on September 21, 2026, at 8:15 PM EDT. Los Angeles enters as a 7-point home favorite with a 47.5-point game total, though their offense carries some uncertainty since star wide receiver Puka Nacua missed practice this week with a hip injury.

I’ll be breaking down a three-leg Giants vs Rams same-game parlay built around Kyren Williams, Davante Adams, and Malik Nabers, with the picks designed to reflect a game script that favors Los Angeles while creating opportunities for New York’s top receiver.

Odds from BetMGM and are subject to change between time of publishing and kickoff.

Williams cleared 63.5 rush yards in two of his last six games—highlighted by an 87-yard performance against Chicago and a 92-yard outing versus Atlanta in 2025—and his established workload in favorable game scripts provides a reliable rushing floor. When these teams clashed on December 31, 2023, Williams shredded New York’s front seven for 87 yards and three touchdowns on 20 carries. He finished 2025 as the NFL’s sixth-leading rusher with 1,252 yards, averaging 4.8 yards per carry on early downs when running out of 11-personnel.

He now faces a Giants defense that ranked 31st in the NFL by surrendering 116.7 rushing yards per game to opposing running backs and 145.3 total rushing yards overall in the 2025 season. With Los Angeles installed as a home favorite, Sean McVay’s ground game will feature Williams on 16 to 19 carries against light box counts to control tempo and clear this total. He was limited to just 11 carries for 41 yards and a score in Week 1, but he should see a bigger workload in this matchup.

While Adams found the end zone in just one of his last six outings (a January 25 clash against Seattle), his high-leverage red-zone usage makes him the premier scoring weapon on the field. During the 2025 campaign, Adams paced the entire NFL with 14 receiving touchdowns during the regular season while commanding a league-leading 31 red-zone targets (a massive 34.8% team red-zone target share). That target concentration expands significantly this week with Puka Nacua (16 red-zone targets and 10 touchdowns in 2025) sidelined by a hip injury, funneling virtually all isolated end-zone looks to Adams.

He draws a Giants defense that tied for 24th last season by surrendering 18 touchdowns to opposing wide receivers. This leg correlates directly with Williams’ rushing prop: sustained ground drives consistently push Los Angeles inside the 20, where McVay utilizes play-action bootlegs to isolate Adams in one-on-one coverage. Even though Adams was held in check by the 49ers in Week 1, limiting him to just three catches for 26 yards in six targets, he should be in line for a better performance on Monday.

Nabers has eclipsed 63.5 receiving yards in four of his last six contests, building on an explosive 2025 injury-shortened campaign (highlighted by a 167-yard performance against Dallas and 71 yards versus Washington) by hauling in six of nine targets for 69 yards in his 2026 opener. Firmly established as New York’s primary perimeter playmaker, Nabers commands a 35.2% team air-yards share and an 88% route participation rate. He faces a Rams secondary that surrendered 147 yards to San Francisco wideouts in Week 1, extending a 2025 defensive vulnerability where Los Angeles ranked 23rd against wide receivers (yielding 150.8 yards per game).